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They activate different intracellular signaling cascades (cAMP/PKA pathway in fat cells vs incretin signaling in gut and brain)

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Neither of these roles has been disproved, but interest in them became somewhat overshadowed by conceptual developments in other directions

The majority of patients (67%) with CGD harbor mutations in an X-chromosome gene (CYBB) that encodes the -subunit (gp91-PHOX) of cytochrome b 558